Malignancy rates in children, young people and adults with JIA: an observational study using CPRD Aurum
Main finding · Malignancy rate per 10 000 person yearsResult — go to the resultHazard ratio 2.2 95% CI 1.2–4.1Authors' conclusion
This study found that those with JIA had a doubling risk for malignancies compared with the matched control population.
Study context
- Population
- Patients with JIA (diagnosed <16 years) in England, UK Primary Care data (CPRD Aurum), 2000–2018matched cohort
- Participants
- 3,714 vs 10,858
- Exposure
- JIA vs matched non-JIA controls
- JIAn = 3,714
- Controlsn = 10,858reference
- Outcome
- Malignancy rates
Methodological detailsmatched 4-to-1 by birth year, gender and practice, Cox proportional hazards models, standardized incidence ratios (SIRs) vs ONS general population estimates
- Matched 4-to-1 by birth year, gender and practice
- Cox proportional hazards models
- SIRs vs ONS general population estimates
Main finding
Malignancy rate per 10 000 person years
Hazard ratio
2.2
95% CI 1.2–4.1
By group
JIAvs Controls
HR 2.2 (95% CI 1.2–4.1)
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Both cohorts had raised SIRs compared with ONS general population estimates
Original publication
Malignancy rates in children, young people and adults with JIA: an observational study using CPRD Aurum. Rheumatology (Oxford). Published 4 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →