Sjögren's disease & overlap diseases
Childhood-onset versus adult-onset Sjögren Syndrome: Clinical phenotype, disease activity, and predictors of organ damage in a national multicenter cohort
Authors' conclusion
coSS displays a distinct clinical phenotype and higher initial disease activity than aoSS, yet accrues less damage over time.
Study context
- Population
- Patients with Sjögren syndrome, national multicenter cohort
- Participants
- 197 patients
- Exposure
- Childhood-onset vs adult-onset Sjögren syndrome
- coSSn = 115
- Adult-onset Sjögren syndrome (aoSS)n = 82reference
- Outcome
- Damage (SSDDI ≥1) and its independent predictors
Methodological detailsnational, multicenter, logistic regression
- National
- Multicenter
- Logistic regression
Main finding
As reported in the abstract
Damage (SSDDI ≥1): independent predictors
Older age at symptom onset, OR
1.044
p<0.001
Higher baseline ESSDAI, OR
1.121
p=0.002
Leukopenia, OR
2.657
p=0.046
RF positivity (protective), OR
0.343
p=0.008
Observational data: associations, not effects.
Further findings
Female sex
P = 0.04
Fulfilment of 2016 ACR/EULAR criteria at baseline
P < 0.001
Diagnostic delay
P = 0.001
| Outcome | coSS | aoSS | P value |
|---|---|---|---|
| Baseline ESSDAI | 9.3 | 5.0 | P < 0.001 |
- SSDDI at last visit · lower in coSS
- P = 0.002
Clinical phenotype
- coSS: more symptomatic parotitis, cervical lymphadenopathy, constitutional symptoms and RP
- aoSS: more sicca symptoms, anti-Ro and RF positivity, leukopenia, lymphopenia and pulmonary involvement
Original publication
Childhood-onset versus adult-onset Sjögren Syndrome: Clinical phenotype, disease activity, and predictors of organ damage in a national multicenter cohort. Semin Arthritis Rheum. Published 18 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →