Sjögren's disease & overlap diseases
TMEM176B is co-expressed with TMEM176A and upregulated in peripheral blood monocytes of patients with primary Sjögren’s syndrome
Authors' conclusion
TMEM176A and TMEM176B are highly correlated. TMEM176B expression in monocytes is linked to pSS and may serve as a novel auxiliary diagnostic biomarker.
Study context
- Population
- Patients with primary Sjögren's Syndrome (pSS) and healthy controls
- Comparison
- pSS patients vs healthy controls
- Outcome
- Proportion of TMEM176B+ cells in monocytes
Methodological detailsbulk RNA-seq and scRNA-seq datasets, flow cytometry immunophenotyping
- Bulk RNA-seq and scRNA-seq datasets
- Flow cytometry immunophenotyping
Main finding
As reported in the abstract
- TMEM176A and TMEM176B showed conserved co-expression and were significantly upregulated in autoimmune diseases
- TMEM176B⁺ monocytes had a higher CD62L positivity rate than TMEM176B- monocytes
- In pSS, the proportion of TMEM176B⁺ monocytes was elevated in total monocytes, classical (classical monocytes (cMo)) and intermediate monocytes (iMo)
Further findings
Clinical correlations
- Proportion of TMEM176B+ monocytes positively correlated with anti-SSB levels; several TMEM176B-associated monocyte subset markers inversely correlated with C4
Original publication
TMEM176B is co-expressed with TMEM176A and upregulated in peripheral blood monocytes of patients with primary Sjögren’s syndrome. Rheumatology (Oxford). Published 17 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →