Sjögren's disease & overlap diseases
Association between maternal autoimmune connective tissue disease and cardiac structure and function in the newborn
Authors' conclusion
In this large population-based study, we did not observe consistent associations between overall maternal CTD and cardiac structure or function in the infant, although minor CHD were more common in newborns exposed to maternal Sjögren's disease.
Study context
- Population
- Newborns who underwent echocardiography in the Copenhagen Baby Heart Study (CBHS)
- Participants
- 25,590 newborns
- Exposure
- Newborns exposed to maternal connective tissue disease (CTD) vs non-exposed newborns
- CTDn = 57
- Outcome
- Structural and functional cardiac parameters
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
- No differences in structural and functional cardiac parameters, overall CTD vs non-exposed
Observational data: associations, not effects.
Further findings
| Outcome | Sjögren's disease | Unexposed | P value |
|---|---|---|---|
| Minor CHDs (atrial and ventricular septal defects, bicuspid aorta valve, patent ductus arteriosus), Sjögren's disease subgroupSjögren's disease vs Unexposed | 33.3% | 7.6% | P = 0.03 |
Original publication
Association between maternal autoimmune connective tissue disease and cardiac structure and function in the newborn. Lupus. Published 13 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →