Sjögren's disease & overlap diseases
Interstitial lung disease in mixed connective tissue disease: Insights from an electronic health record-based retrospective cohort study
Authors' conclusion
ILD affected roughly half of patients with MCTD in this EHR-based cohort. PH and older age were independently associated with ILD
Study context
- Population
- Adults with mixed connective tissue disease (MCTD) (adapted Kasukawa classification algorithm) evaluated at a large urban academic medical center, 2014–2026
- Participants
- 120 adults
- Exposure
- Clinical features associated with interstitial lung disease (ILD) presence in MCTD
- ILDn = 61
- Outcome
- Predictors of ILD presence in MCTD
Methodological detailsElectronic health record (EHR)-based, single-centre, multivariable logistic regression, Cox proportional hazards with time-dependent ILD status, prespecified sensitivity analysis
- EHR-based
- Single-centre
- Multivariable logistic regression
- Cox proportional hazards with time-dependent ILD status
- Prespecified sensitivity analysis
Main finding
As reported in the abstract
ILD
50.8%
61
Odds ratio (95% CI)P value
PHindependently associated with ILD
5.10(1.91–13.63)
P = 0.001Age 55-74 yearsindependently associated with ILD
7.61(1.74–33.33)
P = 0.007GERDdid not reach statistical significance after adjustment
3.16(0.92–10.79)
P = 0.067Observational data: associations, not effects.
Further findings
Mortality by ILD status (survival analysis, n = 120, 11 deaths)
| Estimate | P value | ||
|---|---|---|---|
| ILD | time-dependent HR 2.57 (95% CI 0.74–8.94) | P = 0.137 | |
| ILD | age-adjusted HR 2.60 (95% CI 0.75–9.03) | P = 0.134 | |
| 0.10.31310Ratio (log scale) |
Original publication
Interstitial lung disease in mixed connective tissue disease: Insights from an electronic health record-based retrospective cohort study. Semin Arthritis Rheum. Published 11 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →