Sjögren's disease & overlap diseases
The prevalence of pulmonary arterial hypertension in patients with mixed connective tissue disease: a systematic review and meta-analysis
Authors' conclusion
This is the first systematic review and meta-analysis investigating the prevalence of PAH in patients with MCTD and it revealed an overall prevalence of PAH in patients with MCTD of 12.53%.
Study context
- Population
- Patients with MCTD; RCTs and observational/original studies on PAH, January 1972 to December 2020
- Participants
- 983 patients8 studies
- Outcome
- Prevalence of PAH in MCTD
Methodological detailsrandom-effects meta-analysis (DerSimonian and Laird)
- Random-effects meta-analysis (DerSimonian and Laird)
Pooled result
As reported in the abstract
Pooled prevalence of PAH in MCTD
Pooled prevalence
12.53%
95% CI 8.30–18.48%
Further pooled results
Association of PAH with female gender or age
- No association between PAH and female gender or age
Deaths in MCTD due to PAH
- Percentage of deaths in MCTD due to PAH varied, up to
- 81.8%
Original publication
The prevalence of pulmonary arterial hypertension in patients with mixed connective tissue disease: a systematic review and meta-analysis. Clin Exp Rheumatol. Published 25 February 2023. doi:10.
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