Sjögren's disease & overlap diseases
Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease
Authors' conclusion
Distinct DNA methylation changes precede lymphoma in SjD, affecting genes involved in immune regulation, cytotoxic function, and proliferation.
Study context
- Population
- Patients with primary Sjögren's disease (SjD) with peripheral blood DNA samples collected between 1998 and 2013
- Participants
- 6 vs 84
- Exposure
- Patients with SjD who later developed lymphoma vs patients with SjD who did not
- SjD pre-lymphoman = 6
- Only SjDn = 84reference
- Outcome
- Differentially methylated CpG positions (DMPs; Bonferroni-corrected P ≤ 1.3 × 10-7 and |Δβ| > 0.05) associated with subsequent lymphoma
Methodological detailsnested in a cohort, Illumina HumanMethylation450K BeadChip, adjusted for age, sex and estimated blood cell-type proportions, exploratory
- Nested in a cohort
- Illumina HumanMethylation450K BeadChip
- Adjusted for age, sex and estimated blood cell-type proportions
- Exploratory
Main finding
As reported in the abstract
DMPs distinguishing SjD pre-lymphoma from only SjD
- Autosomal DMPs
- 473
- X-chromosomal DMPs
- 1
- DMPs hypomethylated in SjD pre-lymphoma
- 87%
- Most significant DMP: TK1, P
- P = 7.6 × 10-15
- Most significant DMP: TK1, Δβ
- −0.16
Observational data: associations, not effects.
Further findings
Estimated blood cell-type proportions
- SjD pre-lymphoma had reduced natural killer cells and increased monocyte proportions
Original publication
Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease. Arthritis Rheumatol. Published 9 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →