Sjögren's disease & overlap diseases
Integrating basal and reserve salivary function defines clinically anchored functional phenotypes and contextualises salivary end points in Sjögren’s disease
Authors' conclusion
Integrated basal-reserve functional phenotyping defines clinically and structurally anchored salivary gland functional states in SjD.
Study context
- Population
- Anti-SSA-positive patients with Sjögren's disease (SjD)
- Participants
- 193 patients
- Exposure
- Salivary functional phenotypes by unstimulated whole salivary flow (UWSF) and Saxon test: LL and PL/LP vs PP
- Outcome
- ESSPRI dryness and swallowing difficulty, LL vs PP
Methodological detailsmultivariable adjustment, longitudinal analysis
- Multivariable adjustment
- Longitudinal analysis
Main finding
As reported in the abstract
Each group vs PPOdds ratio (swallowing difficulty) (95% CI)
LL
6.19(2.71–14.9)
- LL
- β (ESSPRI dryness) 1.67 (95% CI 0.64–2.70)
Observational data: associations, not effects.
Further findings
Submandibular gland (SMG) preservation (histology)
- Markedly reduced SMG preservation in LL
Longitudinal UWSF and Saxon test change
- PP: measurable declines in UWSF and Saxon test
- PL/LP: relatively stable
- LL: minimal change in UWSF, directionally positive Saxon slope (floor-constrained end point behaviour rather than biological recovery)
Baseline-to-last phenotype transitions
- Substantial same-phenotype retention; most longitudinally evaluable LL patients remained below the impaired Saxon threshold throughout follow-up
Original publication
Integrating basal and reserve salivary function defines clinically anchored functional phenotypes and contextualises salivary end points in Sjögren’s disease. RMD Open. Published 8 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →