Sjögren's disease & overlap diseases
Evaluation of a Practical Approach to Diagnosis of Sjögren Disease in Clinical Practice
Authors' conclusion
SjD could be diagnosed according to 2016 AECC in most patients on the basis of ST, USSF, and serology results where there is concern for the disease on clinical evaluation. Patients who required further testing for diagnosis had some distinctive features.
Study context
- Population
- Patients evaluated on protocol 1993–2019 at the University Health Network Multidisciplinary Sjogren's Clinic, with complete evaluation incl. serology, ocular surface staining and minor salivary gland (MSG) biopsy
- Participants
- 374 patients
- Exposure
- Group A vs Group B vs Group C
- Group An = 263
- Outcome
- Utility of incorporating the 2016 ACR/EULAR classification criteria (AECC) tools into clinical practice for SjD diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
SjD diagnosis by approach
Observational data: associations, not effects.
Further findings
Serology in groups B and C
- Groups B and C together frequently seronegative (ANA and/or anti-Ro) or antimitochondrial antibody positive
Positive MSG biopsy in seronegative patients with abnormal Schirmer test (ST) and unstimulated salivary flow (USSF)
- Positive MSG biopsy
- 70%
Original publication
Evaluation of a Practical Approach to Diagnosis of Sjögren Disease in Clinical Practice. J Rheumatol. Published 15 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →