Sjögren's disease & overlap diseases
The diagnostic value and clinical relevance of salivary gland ultrasound in patients with highly suspected Sjögren’s Disease: a prospective monocentric study
Authors' conclusion
Although the discriminatory efficacy of SGUS in patients highly suspected of SjD is suboptimal, SGUS may offer significant benefits for a specific subgroup of these patients. Grade 3 ultrasound findings are strongly associated with positive biopsy results and USFR, indicating a potential role in diagnosis and disease evaluation.
Study context
- Population
- Patients with high suspicion of SjD130 diagnosed with SjD
- Participants
- 171 patients
- Comparison
- Salivary gland ultrasound (SGUS) vs labial salivary gland biopsy (LSGB) and anti-Ro/SSA antibodies for diagnosis of SjD
- Outcome
- Diagnostic accuracy of SGUS for SjD
Methodological detailscross-sectional, prospective cohort, monocentric
- Cross-sectional
- Prospective cohort
- Monocentric
Performance
As reported in the abstract
Diagnosis of SjD
| Test or model | AUC | Sensitivity | Specificity |
|---|---|---|---|
| SGUS | 0.78 | 0.52 | 0.93 |
| LSGB | 0.90 | — not stated in the abstract | — not stated in the abstract |
| Anti-Ro/SSA | 0.79 | — not stated in the abstract | — not stated in the abstract |
AUC
SGUS0.78
LSGB0.90
Anti-Ro/SSA0.79
Sensitivity
SGUS0.52
LSGB— not stated in the abstract
Anti-Ro/SSA— not stated in the abstract
Specificity
SGUS0.93
LSGB— not stated in the abstract
Anti-Ro/SSA— not stated in the abstract
— not stated in the abstract
Further findings
SGUS OMERACT total score combined with anti-SSA antibodies or LSGB
- Specificity of combination
- 1.00
PG vs SMG ultrasound grading
- Diagnostic accuracy comparable; SMG grading higher sensitivity but lower specificity than PG grading
SGUS grade 3 predicting positive biopsy
- AUC
- 0.77
Correlation of SGUS grading with unstimulated salivary flow rates (USFR)
- Spearman coefficient, PG
- −0.45
- Spearman coefficient, SMG
- −0.51
Original publication
The diagnostic value and clinical relevance of salivary gland ultrasound in patients with highly suspected Sjögren’s Disease: a prospective monocentric study. Arthritis Res Ther. Published 2 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →