Sjögren's disease & overlap diseases
Diagnostic utility of salivary gland ultrasonography in suspected primary Sjögren’s disease: a comparison of OMERACT-based ordinal and summative scoring
Authors' conclusion
Although overall diagnostic performance was modest, SGUS scoring based on OMERACT definitions demonstrated high specificity at selected thresholds.
Study context
- Population
- Consecutive patients with suspected primary Sjögren’s disease (SjD) undergoing salivary gland ultrasonography (SGUS) of the four major salivary glands23 biopsy-positive (38.3%)
- Participants
- 60 patients
- Comparison
- SGUS ordinal score (0-6) vs SGUS sum score (0-12), both derived from OMERACT 0-3 grading
- Outcome
- Diagnostic accuracy (ROC curve analysis) vs labial salivary gland biopsy
Methodological detailsconsecutive patients, labial salivary gland biopsy as reference standard, ROC curve analysis
- Consecutive patients
- Labial salivary gland biopsy as reference standard
- ROC curve analysis
Performance
As reported in the abstract
Diagnostic accuracy vs labial biopsy
| Test or model | AUC | Specificity at threshold ≥ 4 | Specificity at ≥ 5 |
|---|---|---|---|
| Ordinal score | 0.687 (95% CI: 0.546-0.828) | 91.9% (95% CI: 83.1-100%) | — not stated in the abstract |
| Sum score | 0.683 (95% CI: 0.543-0.824) | — not stated in the abstract | 89.2% (95% CI: 79.2-99.2%) |
AUC
Ordinal score0.687 (95% CI: 0.546-0.828)
Sum score0.683 (95% CI: 0.543-0.824)
Specificity at threshold ≥ 4
Ordinal score91.9% (95% CI: 83.1-100%)
Sum score— not stated in the abstract
Specificity at ≥ 5
Ordinal score— not stated in the abstract
Sum score89.2% (95% CI: 79.2-99.2%)
— not stated in the abstract
Further findings
Biopsy-positive cases in which labial biopsy could potentially have been deferred
| Outcome | P value |
|---|---|
| Association with anti-Ro52 antibody positivityOrdinal score · score ≥ 2 | P = 0.017 |
| Association with anti-Ro52 antibody positivitySum score · score ≥ 3 | P = 0.007 |
- Biopsy-positive cases in which labial biopsy could potentially have been deferred: at high-specificity thresholds (ordinal ≥ 4; sum score ≥ 5)
Original publication
Diagnostic utility of salivary gland ultrasonography in suspected primary Sjögren’s disease: a comparison of OMERACT-based ordinal and summative scoring. Arthritis Res Ther. Published 19 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →