Sjögren's disease & overlap diseases
Serological Stratification by Anti-Ro52 and Anti-Ro60 Profiles Reveals Distinct Systemic Phenotypes in Primary Sjögren's Disease
Authors' conclusion
Anti-Ro52 and anti-Ro60 profiles delineate distinct clinical subsets of pSjD. Anti-Ro52 positivity is associated with greater disease severity, while double positivity defines a unique subgroup with multi-organ involvement and immune hyperactivation
Study context
- Population
- Patients with primary Sjögren's disease (pSjD)
- Participants
- 725 patients
- Exposure
- Anti-Ro52/Ro60 serological profiles vs Ro52-Ro60-
- Outcome
- Systemic involvement in pSjD by anti-Ro profile
Methodological detailsmultivariable logistic regression adjusted for confounders via LASSO, additive interaction analysis (RERI, AP, synergy index (SI))
- Multivariable logistic regression adjusted for confounders via LASSO
- Additive interaction analysis (RERI, AP, SI)
Main finding
As reported in the abstract
Systemic involvement by anti-Ro profile (adjusted)
Each group vs Ro52-Ro60-Odds ratio (95% CI)P value
Ro52+Ro60+renal involvement
5.53(2.56–11.97)
P < 0.001Ro52+Ro60+cutaneous involvement
2.49(1.08–5.75)
P = 0.032Ro52+Ro60+hyperglobulinemia
5.19(2.96–9.10)
P < 0.001Ro52+Ro60+low complement levels
1.70(1.07–2.71)
P = 0.025Ro52+Ro60-ILD
4.17(2.33–7.46)
P < 0.001Observational data: associations, not effects.
Further findings
Additive interaction between anti-Ro52 and anti-Ro60 for hyperglobulinemia (synergistic)
- Adjusted RERI
- 3.00 (95% CI 0.87-5.14)
- AP
- 0.58 (95% CI 0.31-0.84)
- SI (95CI 1.04-11.94)
- 3.52
Original publication
Serological Stratification by Anti-Ro52 and Anti-Ro60 Profiles Reveals Distinct Systemic Phenotypes in Primary Sjögren's Disease. Semin Arthritis Rheum. Published 10 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →