Sjögren's disease & overlap diseases
Hormonal transitions across the lifespan shape susceptibility to Sjogren’s disease
Authors' conclusion
Age-dependent hormonal changes correspond with evolving sex bias in SjD, challenging the static 9:1 female-to-male paradigm.
Study context
- Population
- Electronic health records of sjogren's disease (SjD) patients and controls across age groups
- Exposure
- SjD patients vs controls
- SjDn = 101,856
- Controlsn = 1.33 millionreference
- Outcome
- Sex-specific prevalence of SjD across age groups, compared with serum testosterone, oestradiol and SHBG levels
Methodological detailselectronic health records, National Health and Nutrition Examination Survey (NHANES) hormone data incorporated using imputation, generalized linear models
- Electronic health records
- NHANES hormone data incorporated using imputation
- Generalized linear models
Main finding
As reported in the abstract
Male prevalence among SjD patients by age
Early childhood (peak), 95% CI 26.2-34.1
30.1%
Late puberty into adulthood, 95% CI 9.5-10.2
9.8%
Older adults, 95% CI 13.3-13.8
13.5%
Observational data: associations, not effects.
Further findings
Hormone concentrations, SjD vs controls
- Did not differ significantly between SjD patients and controls
Original publication
Hormonal transitions across the lifespan shape susceptibility to Sjogren’s disease. Rheumatology (Oxford). Published 18 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →