Sjögren's disease & overlap diseases
A Scoping Review and Meta‐Analysis of Proportions of Central Nervous System Manifestations Reported in Patients with Sjögren's Disease
Authors' conclusion
The spectrum of CNS involvement in Sjögren's disease is broad and heterogeneous.
Study context
- Population
- Individuals living with SjD; MEDLINE, Embase (1980–January 29, 2026) and ECRI Guidelines Trust (2020–January 29, 2026)108 studies
- Outcome
- Proportion of individuals with SjD who experience CNS manifestations
Methodological detailsduplicate screening, prespecified inclusion and exclusion criteria, a priori sensitivity analyses for statistical outliers
- Duplicate screening
- Prespecified inclusion and exclusion criteria
- A priori sensitivity analyses for statistical outliers
Pooled result
As reported in the abstract
Pooled proportions of CNS manifestations
- Pooled proportion estimates generated for 23 central nervous system (CNS) manifestations
- Frequencies exceeding those in the general population: depression, migraine, insomnia, cognitive dysfunction, psychosis, movement disorders, aseptic meningoencephalitis, neuromyelitis optica spectrum disorder, optic neuritis, multiple sclerosis, cerebral vasculitis, cerebellar syndrome, spinal cord involvement, non-localizing somatosensory complaints
- Degree of increased frequency differed substantially across manifestations; several estimates highly influenced by individual studies (sensitivity analyses)
Original publication
A Scoping Review and Meta‐Analysis of Proportions of Central Nervous System Manifestations Reported in Patients with Sjögren's Disease. Arthritis Care Res (Hoboken). Published 21 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →