Sjögren's disease & overlap diseases
Single‐Cell RNA Sequencing of Peripheral Blood Defines Two Immunologic Subtypes of Sjögren's Disease Distinguished by Anti‐ SSA Antibodies and Aberrant B Cell Populations
Authors' conclusion
These findings support a two-disease model of SjD and highlight transitional B cells as both a key biomarker and a therapeutic target.
Study context
- Population
- Participants stratified by sjögren's disease (SjD) diagnosis and anti-SSA status; 1.5 million peripheral blood mononuclear cells
- Participants
- 333 participants1.5 million PBMCs
- Comparison
- SjD stratified by anti-SSA status vs symptomatic non-SjD controls
- Outcome
- Peripheral immune cell states
Methodological detailssingle-cell RNA sequencing with surface protein profiling
- Single-cell RNA sequencing with surface protein profiling
Main finding
As reported in the abstract
- Two immunologic endotypes of SjD identified
- SSA-positive: dominant and persistent type I interferon signature, associated with altered immune cell composition
- Transitional B cells in SSA-positive: altered developmental states, reduced BCR diversity, shorter CDR3 regions, increased predicted interactions with activated immune cells
- SSA-negative SjD: limited transcriptional differences vs symptomatic non-SjD controls
Original publication
Single‐Cell RNA Sequencing of Peripheral Blood Defines Two Immunologic Subtypes of Sjögren's Disease Distinguished by Anti‐ SSA Antibodies and Aberrant B Cell Populations. Arthritis Rheumatol. Published 7 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →