Sjögren's disease & overlap diseases
Impact of socioeconomic deprivation on risk and disease activity of Sjögren’s disease
Main finding · Odds of SjD vs Sicca by IMD quintileResult — go to the resultOdds ratio 0.26 CI 0.12–0.58Authors' conclusion
Low SES is associated with increased risk of SjD compared to Sicca and with higher immunoglobulin levels. The Sicca cohort may be less deprived than the general population.
Study context
- Population
- Single-centre UK cohort of Sjögren's disease (SjD) and non-Sjögren's Sicca, with local population controls
- Participants
- 256 / 175 / 972
- Exposure
- SjD vs non-Sjögren's Sicca vs population controls, by socioeconomic status (SES)
- SjDn = 256
- Siccan = 175reference
- Population controlsn = 972
- Outcome
- Association of SES (IMD 2019 quintile and highest educational attainment) with SjD diagnosis vs Sicca and population controls
Methodological detailssingle-centre, adjusted logistic regression, population controls matched on age, sex and ethnicity
- Single-centre
- Adjusted logistic regression
- Population controls matched on age, sex and ethnicity
Main finding
Odds of SjD vs Sicca by IMD quintile
Odds ratio
0.26
CI 0.12–0.58
P < 0.001
IMD quintile 2vs IMD quintile 1 (most deprived)
OR 0.26 (CI 0.12–0.58); P < 0.001
As reported in the abstract
- SjD had lower SES than Sicca across Indices of Multiple Deprivation (IMD) and educational attainment
- P = 0.008 and p=0.018
Observational data: associations, not effects.
Further findings
IgG and IgA levels in SjD per unit increase in IMD
- IgG change per unit IMD increase
- 6.03% (−9.84%, −2.05%; p=0.003)
- IgA change per unit IMD increase
- 6.46% (−10.87%, −1.60%; p=0.010)
- Reduction
SES vs population controls
- IMD not a risk factor for SjD
- P = 0.257
- Sicca associated with lower deprivation
- P = 0.003
- Degree level qualification had the highest odds of diagnosis (SjD or Sicca)
Original publication
Impact of socioeconomic deprivation on risk and disease activity of Sjögren’s disease. RMD Open. Published 4 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →