Sjögren's disease & overlap diseases
Sjögren’s disease patients with no hyposalivation and with short oral dryness complaints contain more T cells in salivary gland parenchyma
Authors' conclusion
Our data imply that the pre-SG disease stage in SjD is associated with an increase in CD4+ and CD8+ T cells in saliva-producing tissue areas.
Study context
- Population
- SSA+ Sjögren's disease (SjD) patients and non-SjD sicca patients; parotid salivary gland parenchyma
- Exposure
- SSA+ SjD vs non-SjD sicca controls
- Outcome
- Frequency of CD4+ T cells, CD8+ T cells, NK cells and macrophages in parotid SG parenchyma, and relation to SG dysfunction
Methodological detailsimmunohistochemistry, parotid salivary gland parenchyma
- Immunohistochemistry
- Parotid salivary gland parenchyma
Main finding
As reported in the abstract
CD4+ T-cell frequency in SG parenchyma
Observational data: associations, not effects.
Further findings
CD8+ T-cell frequency in SG parenchyma
CD8+ T-cell frequency in salivary gland (SG) parenchyma
- Significant increase in SjD vs sicca controls
NK cell and macrophage proportions
- Did not differ significantly
CD4+ and CD8+ T-cell frequency by salivary flow and dryness duration (SjD)
- Trend for increase with healthy UWS and SWS flow and shortest oral dryness complaints vs established flow reduction and longer complaints
CD69 expression
- CD4+/CD8+ T cells may derive from a mixture of tissue resident and infiltrated cells
Original publication
Sjögren’s disease patients with no hyposalivation and with short oral dryness complaints contain more T cells in salivary gland parenchyma. Rheumatology (Oxford). Published 20 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →