Sjögren's disease & overlap diseases
Histopathological comparison of Sjögren-related features between paired labial and parotid salivary gland biopsies of sicca patients
Authors' conclusion
Labial and parotid glands from SjD patients contain similar histopathological key features, and thus both glands can be used for diagnosis and classification of SjD.
Study context
- Population
- Patients with sicca complaints suspected of having Sjögren's disease (SjD) (diagnostic cohort)36 SjD, 63 non-SjD
- Comparison
- Labial vs parotid salivary gland biopsies
- Outcome
- Focus score and other SjD histopathological features, agreement between paired labial and parotid biopsies
Methodological detailspaired biopsies, simultaneously obtained labial and parotid biopsies, Expert opinion of three experienced rheumatologists for SjD diagnosis
- Paired biopsies
- Simultaneously obtained labial and parotid biopsies
- Expert opinion of three experienced rheumatologists for SjD diagnosis
Performance
As reported in the abstract
Absolute agreement, focus score
80%
Absolute agreement, (pre-)lymphoepithelial lesions (LELs)
93%
Further findings
B-lymphocytes, germinal centres/mm² and LEL severity (SjD patients only)
- Labial glands had significantly fewer B-lymphocytes and germinal centres/mm², and less severe LELs vs parotid
Original publication
Histopathological comparison of Sjögren-related features between paired labial and parotid salivary gland biopsies of sicca patients. Rheumatology (Oxford). Published 27 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →