Sjögren's disease & overlap diseases
Salivary Gland Ultrasound Score and Hyperglobulinemia in an Age-Stratified Prediction Model for Positive Labial Focus Score in Sjögren Disease
Authors' conclusion
Our SGUS-based predictive model provides an exploratory, hypothesis-generating tool for guiding labial minor salivary gland biopsy decisions in SjD by integrating imaging with clinical variables, enabling personalized risk stratification.
Study context
- Population
- Patients suspected of having Sjögren disease (SjD) (derivation cohort mean age 44.0 years, 94.7% female)derivation cohort
- Participants
- 449 patients
- Outcome
- Labial FS ≥ 1
Methodological detailsprediction model development and validation, prospective recruitment, multivariable logistic regression, internal and external validation
- Prediction model development and validation
- Prospective recruitment
- Multivariable logistic regression
- Internal and external validation
Performance
As reported in the abstract
Prediction of labial FS ≥ 1 (high-risk and low-risk populations)
| Test or model | AUC | Specificity | Sensitivity | PPV | NPV |
|---|---|---|---|---|---|
| Age-stratified prediction model | 0.91 (95% CI 0.87-0.96, P < 0.001) | 81% | 95% | 92% | 87% |
Age-stratified prediction model
AUC0.91 (95% CI 0.87-0.96, P < 0.001)
Specificity81%
Sensitivity95%
PPV92%
NPV87%
Further findings
Prevalence of labial focus score (FS) ≥ 1 in derivation cohort
- Labial FS ≥ 1
- 284 (63.3%)
Independent predictors of FS ≥ 1 (multivariable logistic regression)
- Salivary gland ultrasound (SGUS) score, OR
- 1.44
- Age, OR
- 1.51
- Hyperglobulinemia, OR
- 1.91
Model validation
- Internal validation (n = 139), AUC
- 0.90
- External validation (n = 57), AUC
- 0.83
Original publication
Salivary Gland Ultrasound Score and Hyperglobulinemia in an Age-Stratified Prediction Model for Positive Labial Focus Score in Sjögren Disease. J Rheumatol. Published 15 March 2026. doi:10.
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