Sjögren's disease & overlap diseases
Non-negligible prevalence of focal lymphocytic sialadenitis in minor salivary glands of non-Sjögren's disease individuals
Authors' conclusion
This study provides compelling epidemiological evidence for the considerably high prevalence of FLS in minor salivary glands of non-SjD individuals.
Study context
- Population
- Non-SjD individuals: Genotype-tissue expression (GTEx) volunteers (autopsy study) and labial minor salivary gland samples from eligible studies (meta-analysis)autopsy
- Participants
- 214 individuals
- Comparison
- Aged ≥60 years vs Aged <60 years
- Outcome
- Prevalence of FLS in labial minor salivary glands of non-SjD individuals
Methodological detailssubgroup analysis by gender
- Subgroup analysis by gender
Pooled result
As reported in the abstract
Prevalence of FLS in labial minor salivary glands
Frequency of focal lymphocytic sialadenitis (FLS), autopsy study (214 GTEx volunteers)
13.1%
Pooled prevalence of FLS in non-SjD individuals, meta-analysis (8 studies, 917 samples)
6.2%
Further pooled results
Prevalence of FLS by age, autopsy study
P = 0.03
Pooled prevalence of FLS by gender, meta-analysis (subgroup)
- Female non-SjD individuals
- 10.4%
- Male non-SjD individuals
- 5.0%
Original publication
Non-negligible prevalence of focal lymphocytic sialadenitis in minor salivary glands of non-Sjögren's disease individuals. Clin Exp Rheumatol. Published 30 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →