Sjögren's disease & overlap diseases
Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll‐Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome‐Associated Membrane Protein 3
Authors' conclusion
Epithelial LAMP3 misexpression can be induced through enhanced type I IFN response in salivary glands. In addition, LAMP3 can promote type I IFN production via ectopic TLR-7 expression in salivary gland epithelial cells.
Study context
- Population
- Minor salivary glands from patients with Sjögren's disease (SjD), submandibular glands from a mouse model of SjD, and salivary gland epithelial cell lines
- Outcome
- Induction of epithelial LAMP3 misexpression and its downstream effects in SjD
Methodological detailsRNA sequencing of human minor salivary glands, mouse submandibular glands and salivary gland epithelial cell lines, in vitro and in vivo assays with gene manipulation
- RNA sequencing of human minor salivary glands, mouse submandibular glands and salivary gland epithelial cell lines
- In vitro and in vivo assays with gene manipulation
Main finding
As reported in the abstract
- LAMP3 expression associated with enhanced type I interferon (IFN) and IFNγ signalling pathways in patients with SjD (transcriptome analysis)
- Type I IFN but not IFNγ stimulation induced LAMP3 expression in salivary gland epithelial cells (in vitro)
- LAMP3 overexpression induced ectopic TLR-7 expression and type I IFN production in salivary gland epithelial cells, in vitro and in vivo
- TLR-7 knockout mice did not develop any SjD-related symptoms after LAMP3 induction
Original publication
Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll‐Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome‐Associated Membrane Protein 3. Arthritis Rheumatol. Published 4 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →