Sjögren's disease & overlap diseases
Reduced Deltex1 expression in T cells indicates increased disease activity in Sjögren's disease
Authors' conclusion
Deltex1 may affect the properties of Tregs; thus, it is a potential biomarker of disease activity in SjD.
Study context
- Population
- Sjögren's disease (SjD) patients and age- and sex-matched healthy controls
- Exposure
- SjD patients vs age- and sex-matched healthy controls; low vs high Deltex1 groups
- Outcome
- Deltex1 mRNA expression in peripheral blood T cells (RT-qPCR)
Methodological detailsage- and sex-matched healthy controls
- Age- and sex-matched healthy controls
Main finding
As reported in the abstract
Deltex1 expression in T cells
- Deltex1 expression in T cells significantly lower in SjD than healthy controls
- SjD vs Healthy controls: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Treg MFI of PD-1, CTLA-4, TIM-3, LAG-3 and % IFN-γ+, IL-4+, IL-17A+ TregsLow Deltex1 vs High Deltex1 · significantly higher in low Deltex1 | P < 0.05 |
Correlation of Deltex1 mRNA with fatigue VAS, ESSDAI and ESSPRI
- Fatigue VAS (negative correlation), r; p=0.035
- −0.334
- ESSDAI (negative correlation), r; p=0.021
- −0.364
- ESSPRI (negative correlation), r; p=0.032
- −0.340
Low Deltex1 and clinical manifestations
- Immune thrombocytopenia, P
- P = 0.014
- Vasculitis, P
- 0.002
- Autoimmune thyroiditis, P
- 0.001
Original publication
Reduced Deltex1 expression in T cells indicates increased disease activity in Sjögren's disease. Clin Exp Rheumatol. Published 29 May 2024. doi:10.
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