Sjögren's disease & overlap diseases
Association of mitochondrial RNA expression levels in saliva and plasma with interferon signature gene expression and disease activity in patients with Sjögren disease
Authors' conclusion
Extracellular mt-RNA burden is elevated in SjD, and mt-RNA scores effectively discriminated patients with SjD from HCs. Saliva mt-RNA levels were associated with SjD disease activity
Study context
- Population
- Patients with Sjögren disease (SjD), healthy controls and rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) disease controls; plasma, saliva and/or peripheral blood mononuclear cells (PBMCs)
- Participants
- 111 / 35 / 40 / 40
- Comparison
- Saliva and plasma mt-RNA scores vs ISG scores in distinguishing SjD from healthy controls (HCs)
- SjDn = 111
- HCsn = 35reference
- RAn = 40
- SLEn = 40
- Outcome
- Discriminative ability of composite mt-RNA scores (saliva, plasma) vs ISG scores in distinguishing SjD from HCs (ROC analysis)
Methodological detailscase-control, disease controls (RA, SLE)
- Case-control
- Disease controls (RA, SLE)
Performance
As reported in the abstract
Discrimination of SjD from HCs (AUC)
Saliva mt-RNA score AUC
0.847
Plasma mt-RNA score AUC
0.789
Further findings
| Outcome | P value |
|---|---|
| Plasma mt-RNA scores, SjD vs RA and SLESjD vs RA · significantly higher in SjD | P < 0.05 |
| Plasma mt-RNA scores, SjD vs RA and SLESjD vs SLE · significantly higher in SjD | P < 0.05 |
Association with disease activity in SjD
- Saliva mt-RNA scores positively associated with objective disease activity measures and RP in SjD; plasma mt-RNA scores were not
Association with disease activity in RA and SLE
- RA and SLE disease activity correlated with plasma mt-RNA scores
Original publication
Association of mitochondrial RNA expression levels in saliva and plasma with interferon signature gene expression and disease activity in patients with Sjögren disease. RMD Open. Published 13 May 2025. doi:10.
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