Sjögren's disease & overlap diseases
A cross-sectional observational study of patients with sicca with salivary autoantibodies defines a potential new phenotype of Sjögren’s disease
Authors' conclusion
These data showed a relationship between ocular and oral dryness and the presence of salivary anti-Ro60 antibodies in subjects with NSS.
Study context
- Population
- Subjects at the Oklahoma Medical Research Foundation Sjögren's Research Clinic, classified by ACR/EULAR classification
- Participants
- 446 subjects
- Exposure
- Sjögren's disease (SjD) vs non-Sjögren's sicca (NSS) vs healthy controls
- Outcome
- Presence of salivary anti-Ro60, anti-La and RF (IgG and IgA) antibodies in whole unstimulated saliva
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
Salivary autoantibodies
- NSS subjects with seronegative profiles, detectable salivary autoantibodies and objective measures of dryness
- 88
Observational data: associations, not effects.
Further findings
NSS seronegative, saliva-positive subjects with positive objective examinations of dryness
- Subjects with positive objective dryness examinations (of the 88), possible early-onset SjD or distinct phenotype
- 75
Original publication
A cross-sectional observational study of patients with sicca with salivary autoantibodies defines a potential new phenotype of Sjögren’s disease. Ann Rheum Dis. Published 3 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →