Sjögren's disease & overlap diseases
Novel autoantibodies help diagnose anti-SSA antibody negative Sjögren disease and predict abnormal labial salivary gland pathology
Authors' conclusion
We present novel autoantibodies in SSA- SjD that have good predictive value for SSA- SjD and FS positivity.
Study context
- Population
- Anti-SSA antibody negative sjögren disease (SjD) cases and controls (independent validation cohort)independent validation cohort
- Participants
- 76 / 75 / 41
- Comparison
- SSA- SjD vs sicca-controls and autoimmune-feature controls
- SSA- SjDn = 76
- Sicca-controlsn = 75reference
- Autoimmune-feature controlsn = 41reference
- Outcome
- Novel autoantibodies (IgG peptide binding) to diagnose seronegative SjD
Methodological detailspeptidome array discovery, independent validation cohort, logistic regression with cross-validation
- Peptidome array discovery
- Independent validation cohort
- Logistic regression with cross-validation
Performance
As reported in the abstract
IgG binding to DTD2 peptide
- SSA- SjD vs Sicca-controls: P = 0.004
- SSA- SjD vs Combined controls: P = 0.003
Further findings
| Outcome | P value |
|---|---|
| IgG binding, FS-positive vs FS-negativeFS-positive vs FS-negative | P = 0.010 |
| IgG binding, FS-positive vs FS-negativeFS-positive vs FS-negative · DTD2 peptide; bound more in FS-positive | P = 0.012 |
- IgG binding, focus score (FS)-positive vs FS-negative: retroelement silencing factor-1 peptide; bound more in FS-positive
Predictive model incorporating clinical variables, discrimination
- AUC, SjD vs control
- 74%
- AUC, FS-positive vs FS-negative
- 72%
- Good discrimination
Original publication
Novel autoantibodies help diagnose anti-SSA antibody negative Sjögren disease and predict abnormal labial salivary gland pathology. Ann Rheum Dis. Published 27 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →