Sjögren's disease & overlap diseases
Identification and evolution of predictors of Sjögren's disease-associated mucosa-associated lymphoid tissue lymphoma development over time: a case-control study
Authors' conclusion
Rheumatoid factor was the earliest and most persistent independent predictor of lymphoma.
Study context
- Population
- Patients with SjD fulfilling 2016 ACR-EULAR criteria, three SjD centres (Athens, Greece; Pisa and Udine, Italy); all White, 90% women68 lymphoma cases in V2 dataset
- Participants
- 160 patients
- Comparison
- SjD-associated mucosal-associated lymphoid tissue (MALT) lymphoma vs SjD controls without lymphoma
- Lymphoman = 80
- Controln = 80reference
- Outcome
- MALT lymphoma predictors in SjD present at SjD diagnosis (V1) and 3-4 years before MALT lymphoma diagnosis (V2)
- Follow-up
- V1 (SjD diagnosis) and V2 (3-4 years before lymphoma diagnosis)
Methodological detailsmatched 1:1 on age, sex, disease duration at last follow up and treatment modality, multicentre (three centres), fast correlation-based feature selection and logistic regression, Individual with lived experience of SjD involved in study design
- Matched 1:1 on age, sex, disease duration at last follow up and treatment modality
- Multicentre (three centres)
- Fast correlation-based feature selection and logistic regression
- Individual with lived experience of SjD involved in study design
Main finding
As reported in the abstract
Independent predictors of MALT lymphoma (lymphoma vs matched controls) · V1 (Sjögren's disease diagnosis) and V2 (3-4 years before lymphoma diagnosis)
Odds ratio (95% CI)
Rheumatoid factor, at V1only independent lymphoma predictor at V1
3.33(1.96–5.64)
Rheumatoid factor, at V2
3.66(2.08–6.42)
European League Against Rheumatism Sjögren's Syndrome Disease Activity Index ≥5, at V2
3.88(1.69–8.90)
Observational data: associations, not effects.
Further findings
Disease activity from V1 to V2
- High disease activity attributed to B-cell-derived manifestations: cryoglobulinaemia and glandular, cutaneous and hematological manifestations
Original publication
Identification and evolution of predictors of Sjögren's disease-associated mucosa-associated lymphoid tissue lymphoma development over time: a case-control study. Lancet Rheumatol. Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →