Sjögren's disease & overlap diseases
The clinical phenotype of isolated ocular or oral dryness in Sjögren's disease
Authors' conclusion
Isolated ocular or oral dryness occurs in 8% of the general SjD population. Patients with isolated dry eyes have a lower prevalence of lymphoma compared to those with isolated dry mouth.
Study context
- Population
- Patients meeting the 2016 ACR-EULAR Sjögren's disease (SjD) criteria, four centres in Greece and Italy
- Participants
- 1,765 patients
- Comparison
- Isolated ocular dryness and isolated oral dryness vs matched controls with both symptoms
- Isolated ocular drynessn = 72
- Ocular dryness controlsn = 144reference
- Isolated oral drynessn = 74
- Oral dryness controlsn = 148reference
- Outcome
- Glandular and extra-glandular manifestations vs matched controls
Methodological detailsmatched 1:2 on age at SjD diagnosis, gender and disease duration, multicentre, Median disease duration 3 years in both groups
- Matched 1:2 on age at SjD diagnosis, gender and disease duration
- Multicentre
- Median disease duration 3 years in both groups
Main finding
As reported in the abstract
- Isolated ocular dryness vs Ocular dryness controls: P = 0.05
- Isolated ocular dryness vs Ocular dryness controls: P = 0.001
- Isolated oral dryness vs Oral dryness controls: P = 0.0003
- Isolated oral dryness vs Oral dryness controls: P = 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Isolated oral vs isolated ocular drynessIsolated oral dryness vs Isolated ocular dryness | P = 0.005 |
| Isolated oral vs isolated ocular drynessIsolated oral dryness vs Isolated ocular dryness | P = 0.01 |
Original publication
The clinical phenotype of isolated ocular or oral dryness in Sjögren's disease. Clin Exp Rheumatol. Published 20 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →