Sjögren's disease & overlap diseases
The diagnostic power of salivary electrolytes for Sjögren's disease: a systematic literature review and meta-analysis
Authors' conclusion
Despite differences in saliva type, salivary ion levels could be utilised for the screening for SjD.
Study context
- Population
- Studies reporting human salivary ion concentrations in Sjögren's disease (SjD) patients vs healthy controls and/or sicca patients (PubMed, Web of Science, manual search; last search March 2023)21 articles
- Comparison
- SjD vs healthy controls and/or sicca patients
- Outcome
- Diagnostic power of salivary electrolytes (salivary ion concentrations) for SjD
Pooled result
As reported in the abstract
Salivary ion concentrations
- SjD vs healthy controls: significant increase in salivary sodium, chloride and calcium
- SjD vs sicca: significant differences for sodium, chloride, phosphate, calcium, nitrite and nitrate
Further pooled results
Between-study variability by saliva type
- Stimulated whole saliva showed larger between-study variability than unstimulated whole, submandibular/sublingual and parotid saliva
Original publication
The diagnostic power of salivary electrolytes for Sjögren's disease: a systematic literature review and meta-analysis. Clin Exp Rheumatol. Published 19 July 2023. doi:10.
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