Systemic sclerosis & Raynaud's
Whole phenotype of patients with systemic sclerosis and sicca manifestations: Comparison with sicca manifestations from other causes
Authors' conclusion
SjD-SSc overlap have more severe sicca features as compared to isolated sicca-SSc and isolated SjD, suggesting a specific impact of SSc on salivary gland physiology.
Study context
- Population
- Systemic sclerosis (SSc) patients with and without sicca symptoms and patients with sicca symptoms from other causes, assessed with salivary glands Ultrasound (SGUS), minor salivary glands biopsies (mSGB) and clinical findings
- Participants
- 60 / 15 / 65
- Exposure
- SSc with sicca symptoms vs SSc without sicca symptoms vs sicca from other causes (including Sjogren's Disease (SjD))
- Sicca-SScn = 60
- SSc without sicca symptomsn = 15
- Sicca from other causesn = 65reference
- Outcome
- Objective anomalies in SSc with subjective sicca symptoms
Methodological detailsconsecutive recruitment
- Consecutive recruitment
Main finding
As reported in the abstract
Objective clinical anomalies
up to 83 %
Histological anomalies (Focus score≥1/ mm²)
44 %
US anomalies (OMERACT ≥2)
63 %
Observational data: associations, not effects.
Further findings
- OMERACT ≥2 on SGUS: SjD-SSc overlap vs isolated SjD vs isolated Sicca-SSc — Sicca-SSc
- 38%
- OMERACT ≥2 on SGUS: SjD-SSc overlap vs isolated SjD vs isolated Sicca-SSc: SjD-SSc 70%
OMERACT ≥2 on SGUS: SjD-SSc overlap vs isolated SjD vs isolated Sicca-SSc
- SjD-SSc patients had more severe glandular involvement as compared to patients with isolated SjD and isolated Sicca-SSc patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Whole phenotype of patients with systemic sclerosis and sicca manifestations: Comparison with sicca manifestations from other causes. Semin Arthritis Rheum. Published 4 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →