Systemic sclerosis & Raynaud's
T cells of patients with systemic sclerosis or Sjögren’s disease display an aberrant metabolic state and memory phenotype in blood and lungs
Authors' conclusion
In patients with SSc-ILD and SjD-ILD, a disturbed T-cell memory differentiation combined with an exhausted phenotype and reduced metabolic fitness point towards sustained T-cell receptor engagement and chronic stimulation.
Study context
- Population
- Patients with systemic sclerosis (SSc) or Sjögren's disease (SjD) (including SSc- or SjD-associated interstitial lung disease (ILD)) and healthy controls; blood and BAL
- Participants
- 38 / 36 / 34
- Comparison
- SSc and SjD vs healthy controls
- SScn = 38
- SjDn = 36
- Healthy controls (HC)n = 34reference
- Outcome
- T-cell responses in blood and lungs
Methodological detailsspectral flow cytometry, blood and bronchoalveolar lavage
- Spectral flow cytometry
- Blood and bronchoalveolar lavage
Main finding
As reported in the abstract
- SSc: significantly increased CD4+ TEMRA compartment in recirculating blood T cells
- P = 0.0171
Original publication
T cells of patients with systemic sclerosis or Sjögren’s disease display an aberrant metabolic state and memory phenotype in blood and lungs. Rheumatology (Oxford). Published 17 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →