Systemic sclerosis & Raynaud's
Increased CD8+ tissue resident memory T cells, regulatory T cells and activated natural killer cells in systemic sclerosis lungs
Authors' conclusion
SSc-ILD lungs show activated lymphoid populations.
Study context
- Population
- Lymphoid populations from SSc-ILD and healthy control (HC) lung explants
- Participants
- 13 vs 6
- Comparison
- SSc-ILD vs HC lung explants
- SSc-ILDn = 13
- HCn = 6reference
- Outcome
- Lymphoid subpopulations (absolute cell numbers and cell proportions per cluster) in SSc-ILD vs HC lung explants
Methodological detailssingle-cell RNA sequencing, lung explants
- Single-cell RNA sequencing
- Lung explants
Main finding
As reported in the abstract
Lymphoid subpopulations in lung explants
- Activated CD16+ NK cells, CD8+ tissue resident memory T cells and Treg cells proportionately higher in SSc-ILD vs HC lungs
- Activated CD16+ NK cells in SSc-ILD showed upregulated granzyme B, IFN-γ and CD226
- Amphiregulin, highly upregulated by NK cells, predicted to interact with epidermal growth factor receptor on several bronchial epithelial cell populations
- Shifts in CD8+ T cell populations indicated a transition from resting to effector to tissue resident phenotypes in SSc-ILD
Original publication
Increased CD8+ tissue resident memory T cells, regulatory T cells and activated natural killer cells in systemic sclerosis lungs. Rheumatology (Oxford). Published 13 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →