Systemic sclerosis & Raynaud's
Increased oxidative stress response in circulating blood of systemic sclerosis patients – relation to disease characteristics and inflammatory blood biomarkers
Authors' conclusion
Our data indicate a pro-oxidant imbalance in SSc, likely related to systemic inflammation and endothelial injury.
Study context
- Population
- Patients with systemic sclerosis (SSc) and well-matched controls
- Participants
- 55 vs 44
- Comparison
- SSc vs matched controls
- SScn = 55
- Controlsn = 44reference
- Outcome
- Oxidative stress response in peripheral blood: real-time protein hydroperoxide (HP) formation by the coumarin boronic acid (CBA) assay
Methodological detailswell-matched controls
- Well-matched controls
Main finding
As reported in the abstract
HP formation in the CBA assay
Fold faster fluorescent product generation
2-fold
P < 0.001
SSc
Fold higher cumulative hydroperoxide (HP) formation
3-fold
P < 0.001
SSc
Observational data: associations, not effects.
Further findings
Associations of HP generation with disease characteristics
- Not associated with disease form (diffuse vs limited SSc), current immunosuppressive therapy, abnormal nailfold capillaries or autoantibody profile
- Enhanced with more severe illness, pulmonary hypertension, digital ulcers, CYC treatment and in smokers (current or past)
- Higher serum CRP, blood eosinophil count and cellular fibronectin with lower hemoglobin were independent determinants of increased HP formation
Original publication
Increased oxidative stress response in circulating blood of systemic sclerosis patients – relation to disease characteristics and inflammatory blood biomarkers. Semin Arthritis Rheum. Published 9 June 2023. doi:10.
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