Systemic sclerosis & Raynaud's
High-throughput plasma proteomics reveals circulating biomarkers of interstitial lung disease and progressive pulmonary fibrosis in systemic sclerosis
Authors' conclusion
SP-D and MMP-8 emerge as candidate biomarkers for diagnosing SSc-ILD and predicting SSc-PPF, respectively.
Study context
- Population
- Patients with SSc from 3 centres (Paris, Bordeaux, Leeds)discovery n = 45
- Participants
- 202 patients
- Comparison
- SSc-ILD vs SSc-NoILD; SSc-PPF vs SSc-NoPPF
- Outcome
- Plasma biomarkers associated with SSc-ILD and SSc-PPF
Methodological detailsmass spectrometry-based proteomics, discovery and replication cohorts, multicentre
- Mass spectrometry-based proteomics
- Discovery and replication cohorts
- Multicentre
Performance
As reported in the abstract
| Test or model | Value | Biomarker |
|---|---|---|
| SSc-ILD | 17.36 ± 11.99 ng/mL | Surfactant protein D (SP-D) |
| SSc-NoILD | 9.49 ± 7.92 ng/mL | SP-D |
| SSc-PPF | 17.67 ± 12.45 ng/mL | MMP-8 |
| SSc-NoPPF | 10.77 ± 10.92 ng/mL | MMP-8 |
Value
SSc-ILD17.36 ± 11.99 ng/mL
SSc-NoILD9.49 ± 7.92 ng/mL
SSc-PPF17.67 ± 12.45 ng/mL
SSc-NoPPF10.77 ± 10.92 ng/mL
Biomarker
SSc-ILDSP-D
SSc-NoILDSP-D
SSc-PPFMMP-8
SSc-NoPPFMMP-8
- SSc-ILD vs SSc-NoILD: P < 0.0001 — SP-D
- SSc-PPF vs SSc-NoPPF: P < 0.001 — MMP-8
Further findings
Proteomic discovery
- Proteins quantified
- 1507
- Proteins associated with SSc-ILD
- 44
- Proteins associated with SSc-PPF
- 51
- Candidates progressed to enzyme-linked immunosorbent assay (ELISA) validation; SP-D and MMP-8 replicated
- 5
MMP-8 prognostic value for PPF, external cohort (Tokyo and Milan)
- Cohort size
- 113
- Prognostic value replicated
- Combined analyses: MMP-8 independently predicted SSc-PPF and improved performance added to clinical variables
Original publication
High-throughput plasma proteomics reveals circulating biomarkers of interstitial lung disease and progressive pulmonary fibrosis in systemic sclerosis. Ann Rheum Dis. Published 23 July 2026. doi:10.
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