Systemic sclerosis & Raynaud's
Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis
Authors' conclusion
We found a severe cutaneous transcriptomic signature of SSc associated with multiorgan involvement.
Study context
- Population
- Patients with systemic sclerosis (SSc) (skin transcriptomes) and individuals with SSc-ILD (lungs)
- Outcome
- Skin transcriptomic signature and skin/lung involvement
Methodological detailsmultistage transcriptomic analysis, weighted gene correlation analysis, gene set enrichment analysis, single-cell RNA sequencing
- Multistage transcriptomic analysis
- Weighted gene correlation analysis
- Gene set enrichment analysis
- Single-cell RNA sequencing
Main finding
As reported in the abstract
- Modules correlated with skin and lung function involvement
- 7
- Unsupervised clustering classified patients into two groups; one with severe multiorgan involvement: increased skin fibrosis and decreased lung function
- P < 0.05
- Activation of KRAS and downstream signaling in lungs from individuals with SSc-ILD
- P < 0.05
Original publication
Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis. Arthritis Rheumatol. Published 20 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →