Systemic sclerosis & Raynaud's
Shared and unique molecular signatures across different autoantibody groups in systemic sclerosis: a multiomics analysis
Authors' conclusion
Our study addresses a critical gap by providing a comprehensive multiomics characterisation of both common and rare SSc-associated autoantibody groups, revealing shared and distinct molecular signatures that correlate with clinical features.
Study context
- Population
- Patients with systemic sclerosis (SSc) stratified by autoantibody status
- Participants
- 166 patients
- Comparison
- SSc autoantibody subgroups (ACA, ATA, ARA, U1RNP, U3RNP, Ku, Th/To) compared for shared and distinct molecular profiles
- ACAn = 55
- ATAn = 58
- ARAn = 24
- U1RNPn = 12
- U3RNPn = 8
- Kun = 4
- Th/Ton = 5
- Outcome
- Shared and unique molecular signatures (plasma proteomics, PBMC transcriptomics, immune cell phenotyping, plasma metabolomics)
Methodological detailsmultiomics analysis
- Multiomics analysis
Main finding
As reported in the abstract
- All SSc subsets: endothelial injury and extracellular matrix deposition (plasma proteomics)
- All SSc subsets: upregulated type I interferon (IFN) signalling (transcriptomics)
- All SSc subsets: decreased regulatory B cells (immune cell profiling)
- ACA: calcinosis
- ATA: metabolic oxidative stress
- ARA: activation of oncogenic signalling
- U1RNP: enhanced chromatin remodelling activity
- U3RNP/Ku: muscle involvement
- Th/To: unique metabolic signalling related to pulmonary hypertension
Original publication
Shared and unique molecular signatures across different autoantibody groups in systemic sclerosis: a multiomics analysis. Ann Rheum Dis. Published 18 December 2025. doi:10.
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