Systemic sclerosis & Raynaud's
Distinct Effects of Complement C4A and C4B Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes
Main finding · C4 CN association with SSc risk by subgroupResult — go to the resultOdds ratio 1.88Authors' conclusion
This study highlights distinct genetic contributions of C4A and C4B in SSc subtypes susceptibility.
Study context
- Population
- Patients with systemic sclerosis (SSc), by autoantibody and cutaneous subtype, and controls
- Participants
- 4,049 / 2,200 / 577 / 1,078 / 6,295 / 2,946 / 17,991
- Comparison
- SSc serological and clinical subgroups vs controls
- ACA+n = 4,049
- ATA+n = 2,200
- ARA+n = 577
- TNn = 1,078
- lcSScn = 6,295
- dcSScn = 2,946
- Controlsn = 17,991reference
- Outcome
- Association of C4 (C4A, C4B) and HERV-K CN with SSc clinical and serologic subtypes
Methodological detailscase-control, imputed C4 copy numbers
- Case-control
- Imputed C4 copy numbers
Main finding
C4 CN association with SSc risk by subgroup
Odds ratio
1.88
As reported in the abstract
Observational data: associations, not effects.
Further findings
Sex-biased associations
- Stronger C4A effects in dcSSc, ATA+ and ARA+ male patients; stronger C4B effects in ACA+ and lcSSc female patients
HLA alleles
- HLA alleles associated with SSc subgroups appear independent of C4 copy number (CN)
Original publication
Distinct Effects of Complement C4A and C4B Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes. Arthritis Rheumatol. Published 18 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →