Systemic sclerosis & Raynaud's
Phenotype of diffuse cutaneous systemic sclerosis patients with positive anticentromere antibodies: A systematic literature review and meta-analysis
Authors' conclusion
Although uncommon, the ACA-dcSSc subset appears to have a distinct clinical phenotype, with a better prognosis than ATA-dcSSc.
Study context
- Population
- Adult SSc patients with identifiable demographic and clinical features by subtype, observational studies (MEDLINE, Scopus, OVID, January 1970 to April 2023)6 articles
- Participants
- 177 patients
- Comparison
- Anticentromere antibodies (ACA)-dcSSc vs ACA-lcSSc and ATA-dcSSc
- ACA-dcSScn = 177
- Outcome
- Major organ involvement (ILD, PH, PMI, SRC) and mortality
Methodological detailsrandom-effects meta-analysis, Newcastle-Ottawa Scale quality assessment
- Random-effects meta-analysis
- Newcastle-Ottawa Scale quality assessment
Pooled result
As reported in the abstract
ILD
Odds ratio (95% CI)
ACA-dcSScvs ACA-lcSScmore frequent
2.60(1.39–4.87)
ACA-dcSScvs ATA-dcSScless frequent
0.17(0.10–0.29)
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| 10-year mortality · 10 yearsACA-dcSScvs ATA-dcSSc | 0.42 (0.2–0.85) | |
| 0.20.5125Odds ratio (log scale) |
5-year survival
- Comparable among the subsets
Original publication
Phenotype of diffuse cutaneous systemic sclerosis patients with positive anticentromere antibodies: A systematic literature review and meta-analysis. Semin Arthritis Rheum. Published 3 December 2024. doi:10.
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