Systemic sclerosis & Raynaud's
Clinical distinctions of anti-topoisomerase positive limited cutaneous systemic sclerosis in early disease: results from the early Systemic sclerOsis Longitudinal Assessment Registry from Turkey
Authors' conclusion
ATA-positive lcSSc patients exhibit a clinically distinct phenotype characterized by a substantial risk of internal organ involvement, despite having less extensive skin disease.
Study context
- Population
- Early SSc patients from the multicentre Turkish SOLAR cohort295 screened
- Participants
- 172 patients
- Exposure
- ATA-positive limited cutaneous SSc (lcSSc) vs ACA-positive lcSSc and ATA-positive diffuse cutaneous systemic sclerosis (dcSSc)
- ATA-positive lcSScn = 55
- ACA-positive lcSScn = 74reference
- ATA-positive dcSScn = 43
- Outcome
- Demographic, clinical and treatment features compared across groups
Methodological detailsmulticentre, registry-based
- Multicentre
- Registry-based
Main finding
As reported in the abstract
ILD
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Age at onset of RP, first non-RP symptom and diagnosisATA-positive lcSSc vs ACA-positive lcSSc · younger at RP onset | P = 0.042 |
| Age at onset of RP, first non-RP symptom and diagnosisATA-positive lcSSc vs ACA-positive lcSSc · younger at first non-RP symptom | P = 0.016 |
| Age at onset of RP, first non-RP symptom and diagnosisATA-positive lcSSc vs ACA-positive lcSSc · younger at diagnosis | P = 0.018 |
mRSS
- Highest in ATA-positive dcSSc but also significantly elevated in ATA-positive lcSSc
- P < 0.001
Pitting scars, HRCT patterns and treatment
- Pitting scars more frequent in dcSSc
- Among interstitial lung disease (ILD) patients, similar HRCT patterns in ATA-positive lcSSc and ATA-positive dcSSc
- GC and MMF more frequent in ATA-positive lcSSc than ACA-positive lcSSc; CYC highest in dcSSc
Original publication
Clinical distinctions of anti-topoisomerase positive limited cutaneous systemic sclerosis in early disease: results from the early Systemic sclerOsis Longitudinal Assessment Registry from Turkey. Clin Exp Rheumatol. Published 6 December 2025. doi:10.
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