Systemic sclerosis & Raynaud's
Association of onset age with features of patients with systemic sclerosis in the Renji Scleroderma Longitudinal Cohort (Renji-SLOC)
Authors' conclusion
Non-standard onset age predicts distinct organ-specific risks in SSc.
Study context
- Population
- SSc patients in the prospective Renji Scleroderma Longitudinal Cohort (Renji-SLOC)proteomics in 131
- Participants
- 390 patients
- Exposure
- Early-onset vs standard-onset vs late-onset SSc
- Early-onsetn = 73
- Standard-onsetn = 219reference
- Late-onsetn = 98
- Outcome
- Serologic, clinical and proteomic characteristics by age at SSc onset
- Follow-up
- Baseline
Methodological detailsstratified by onset age, plasma proteomic profiling (subset)
- Stratified by onset age
- Plasma proteomic profiling (subset)
Main finding
As reported in the abstract
| Group | Value | Modified Rodnan Skin Score (mRSS) |
|---|---|---|
| Early-onset | 42.5% | 7.0 (9.0) |
| Standard-onset | 23.3% | 4.0 (6.0) |
| Late-onset | 36.7% | 6.0 (14.0) |
Value
Early-onset42.5%
Standard-onset23.3%
Late-onset36.7%
Modified Rodnan Skin Score (mRSS)
Early-onset7.0 (9.0)
Standard-onset4.0 (6.0)
Late-onset6.0 (14.0)
- Early-onset vs Late-onset: P = 0.002 — dcSSc percentage across the three groups (vs Standard-onset)
- Early-onset vs Late-onset: P = 0.002 — mRSS across the three groups (vs Standard-onset)
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Organ involvement risks, Early-onsetEarly-onset vs Standard-onset · severe skin involvement (mRSS > 7) | 2.34 | P = 0.005 |
| Organ involvement risks, Early-onsetEarly-onset vs Standard-onset · ILD | 2.35 | P = 0.005 |
| Organ involvement risks, Late-onsetLate-onset vs Standard-onset · ILD | 1.93 | P = 0.016 |
| Organ involvement risks, Late-onsetLate-onset vs Standard-onset · PAH | 3.46 | P < 0.001 |
| Organ involvement risks, Late-onsetLate-onset vs Standard-onset · diastolic dysfunction | 3.11 | P < 0.001 |
| Organ involvement risks, Late-onsetLate-onset vs Standard-onset · weight loss | 2.67 | P = 0.043 |
| Organ involvement risks, Late-onsetLate-onset vs Standard-onset · joint involvement | 1.68 | P = 0.038 |
Progression · median follow-up 15 months
- No progression differences observed
Plasma proteomics (n = 131)
- Proteins detected after quality control
- 909
- Early-onset: upregulated proteins linked to severe cutaneous involvement and pulmonary fibrosis
- 20
- Late-onset: upregulated proteins enriched in ECM-associated proteins, interstitial lung disease (ILD)-related biomarkers and SSc progression/complication markers
- 90
Original publication
Association of onset age with features of patients with systemic sclerosis in the Renji Scleroderma Longitudinal Cohort (Renji-SLOC). Rheumatology (Oxford). Published 29 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →