Systemic sclerosis & Raynaud's
Nailfold capillaroscopy by dermatoscope in systemic sclerosis: a systematic review and meta-analysis
Authors' conclusion
Limited data demonstrate DNC offers high specificity but moderate sensitivity for identifying scleroderma patterns in SSc, making it a valuable initial screening tool for resource-limited settings in patients with Raynaud's phenomenon. While DNC cannot replace NVC for detailed microvascular assessment, its ease of use, portability, and diagnostic performance support implementation for mainly triage of capillary abnormalities in SSc and connective tissue diseases in routine clinical practice.
Study context
- Population
- Studies in adults assessing sensitivity and specificity of dermatoscope-based nailfold capillaroscopy (DNC) versus nailfold videocapillaroscopy (NVC) or stereomicroscopy for the scleroderma pattern in systemic sclerosis (SSc)participants in three included studies
- Participants
- 340 participants
- Comparison
- DNC versus NVC or stereomicroscopy
- Outcome
- Diagnostic accuracy of DNC in detecting scleroderma capillary patterns (pooled)
Methodological detailsPRISMA-DTA guidelines, Univariate and bivariate random-effects meta-analysis
- PRISMA-DTA guidelines
- Univariate and bivariate random-effects meta-analysis
Pooled result
As reported in the abstract
Pooled sensitivity
56%
95% CI 39–80%
Pooled specificity
95%
95% CI 91–100%
Pooled diagnostic odds ratio
31.83
95% CI 16.85–60.15
AUC
0.895
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →