Systemic sclerosis & Raynaud's
Nailfold videocapillaroscopy patterns in systemic sclerosis: implications for cutaneous subsets, disease features and prognostic value for survival
Authors' conclusion
SSc patients with Late pattern more frequently present dcSSc and develop more fibrotic and vascular manifestations. Advanced microangiopathy by NVC identifies dcSSc patients at risk of reduced survival due to SSc-related causes.
Study context
- Population
- Systemic sclerosis (SSc) patients from the RESCLE registry (88% women; 987 lcSSc/251 dcSSc)
- Participants
- 1,356 patients
- Exposure
- Late nailfold videocapillaroscopy (NVC) scleroderma pattern vs non-Late pattern
- Late patternn = 540
- non-Late patternn = 816reference
- Outcome
- Associations of NVC scleroderma pattern with disease features, and prognostic value for survival
Methodological detailsRESCLE registry, multivariate Cox regression
- RESCLE registry
- Multivariate Cox regression
Main finding
As reported in the abstract
Associations of Late pattern with disease features · baseline
Odds ratio
1.96
P < 0.001
dcSSc
Odds ratio
1.29
P = 0.031
Interstitial lung disease (ILD)
Odds ratio
3.46
P < 0.001
scleroderma renal crisis
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Associations with Late pattern, cutaneous subset disregarded (alternative analysis)Anti-topoisomerase I antibodies | 1.39 | P < 0.036 |
| Associations with Late pattern in dcSSc (subgroup)Late pattern vs non-Late pattern · acro-osteolysis | 2.13 | P = 0.022 |
| Associations with Late pattern in dcSSc (subgroup)Late pattern vs non-Late pattern | 2.24 | P < 0.001 |
| Associations with Late pattern in lcSSc (subgroup): ILD | 1.38 | P = 0.028 |
| Survival in dcSSc (subgroup)Survival reduced with Late pattern | P = 0.049 |
- Associations with Late pattern in dcSSc (subgroup): systolic pulmonary artery pressure >40 mmHg by Doppler echocardiogram
Risk factors for SSc mortality (multivariate Cox)
- Age at diagnosis HR
- 1.03; p<0.001
- dcSSc HR
- 2.48; p<0.001
- Digital ulcers (DU) HR
- 1.38; p=0.046
- ILD HR
- 2.81; p<0.001
- PAH HR
- 1.99; p<0.001
Original publication
Nailfold videocapillaroscopy patterns in systemic sclerosis: implications for cutaneous subsets, disease features and prognostic value for survival. Clin Exp Rheumatol. Published 1 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →