Systemic sclerosis & Raynaud's
Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis
Authors' conclusion
In contrast to ACA-positive patients, ATA-positive patients show signs of recent activation of the B cell response that hallmarks this disease. The degree of activation correlates with the presence and severity of ILD, the most deleterious disease manifestation.
Study context
- Population
- Patients with systemic sclerosis (SSc) positive for anti-topoisomerase (anti-topoisomerase antibodies (ATA)) or anti-centromere (anti-centromere antibodies (ACA)) antibodies
- Participants
- 22 vs 20
- Comparison
- ATA-positive vs ACA-positive SSc
- ATA-positiven = 22
- ACA-positiven = 20reference
- Outcome
- Autoreactive B cell responses
Methodological detailsex vivo PBMC culture, cell sorting of antibody secreting cells
- Ex vivo PBMC culture
- Cell sorting of antibody secreting cells
Main finding
As reported in the abstract
- Spontaneous ATA-secretion higher in patients with interstitial lung disease (ILD) than without
- p<0.001
- Spontaneous ATA-secretion correlated with degree of pulmonary fibrosis
- p<0.001
Original publication
Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis. RMD Open. Published 28 July 2023. doi:10.
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