Systemic sclerosis & Raynaud's
Distinct metabolic profiles of circulating plasmacytoid dendritic cells in systemic sclerosis patients stratified by clinical phenotypes
Authors' conclusion
Our results suggest that pDCs from ACA+ patients rely more on oxidative phosphorylation (OXPHOS) and are more responsive to external stimuli, whereas pDCs from ATA+ patients may exhibit a more activated or exhausted profile.
Study context
- Population
- Circulating plasmacytoid dendritic cells (pDCs) (CD304+ Lin-) from healthy donors and systemic sclerosis (SSc) patients, at steady-state or stimulated with CpG A
- Comparison
- pDC metabolic profile in SSc patients stratified by autoantibody and cutaneous subset vs healthy donors
- Healthy donorsn = tenreference
- SScn = fourteen
- Outcome
- Metabolic profile of circulating pDCs
Methodological detailssingle-cell flow cytometry-based (SCENITH™)
- Single-cell flow cytometry-based (SCENITH™)
Main finding
As reported in the abstract
pDC metabolic profile
- ACA+ pDCs: higher mitochondrial dependence and lower glycolytic capacity than ATA+ pDCs
- ACA+ and limited cutaneous SSc (lcSSc) pDCs: stronger response to TLR9 activation than ATA+, ARA+ or diffuse cutaneous SSc (dcSSc) pDCs
Original publication
Distinct metabolic profiles of circulating plasmacytoid dendritic cells in systemic sclerosis patients stratified by clinical phenotypes. Arthritis Res Ther. Published 19 February 2025. doi:10.
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