Systemic sclerosis & Raynaud's
Clinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin
Authors' conclusion
Classification by IS identifies patients with distinct clinical phenotypes versus traditional cutaneous or autoantibody classification.
Study context
- Population
- Systemic sclerosis (SSc) patients and healthy participants, multicentre165 SSc, 58 healthy participants (HPs)
- Participants
- 223 patients
- Exposure
- Intrinsic subset (skin gene expression) classification vs traditional cutaneous and serum autoantibody classification
- dcSScn = 115
- lcSScn = 50
- HPsn = 58reference
- Outcome
- mRSS by intrinsic subset (Inflammatory IS vs other ISs) and cutaneous subset (dcSSc), mean ± SD
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Inflammatory intrinsic subset (IS)
22.1
SD 9.9
dcSSc
19.4
SD 9.4
Inflammatory IS vs Other ISs: P < 0.001 · Inflammatory IS vs dcSSc: P = 0.05
Observational data: associations, not effects.
Original publication
Clinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin. Arthritis Care Res (Hoboken). Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →