Systemic sclerosis & Raynaud's
Skin biopsy analysis of concurrent keloidal morphoea and systemic sclerosis confirms overlapping pathogenic pathways
Authors' conclusion
Understanding the biology of keloidal morphoea may give valuable insight into the molecular and cellular pathology of systemic sclerosis.
Study context
- Population
- Patients with keloidal morphoea concurrent with systemic sclerosis
- Comparison
- Keloidal lesion skin vs skin elsewhere; also dcSSc or lcSSc without morphoea and healthy control skin
- Outcome
- Skin gene expression
Main finding
As reported in the abstract
- Keloidal morphoea has a distinct gene expression signature, mainly driven by differential expression of fibroblast-related genes compared with other cell types
- The signature reflects a profibrotic pattern seen in dcSSc but is much more extreme
Original publication
Skin biopsy analysis of concurrent keloidal morphoea and systemic sclerosis confirms overlapping pathogenic pathways. Clin Exp Rheumatol. Published 1 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →