Systemic sclerosis & Raynaud's
High prevalence and incidence of systemic sclerosis in Reunion Island, a French multi-ethnical and tropical territory
Authors' conclusion
Our study revealed high prevalence and incidence of SSc in Reunion Island which is consistent with the frequently described higher frequency among patients of African origin.
Study context
- Population
- Systemic sclerosis (SSc) cases (ACR/EULAR 2013 criteria), Reunion Island, 2005–2021175 SSc, 32 MCTD
- Participants
- 207 cases
- Exposure
- lcSSc vs dcSSc vs ssSSc vs MCTD
- lcSScn = 108
- dcSScn = 58
- ssSScn = 9
- MCTDn = 32
- Outcome
- SSc prevalence (2021) and mean annual incidence (2005-2021), adjusted to WHO standards
- Follow-up
- 2021
Methodological detailsmultiple-source case retrieval, WHO standard adjustment
- Multiple-source case retrieval
- WHO standard adjustment
Main finding
As reported in the abstract
Prevalence per 100,000 inhabitants in 2021 (95 %IC: 26.1-35.8)
30.9
Mean annual incidence per 100,000 inhabitants/year, 2005-2021 (95 %IC: 1.81-2.45)
2.13
Observational data: associations, not effects.
Further findings
Survival after diagnosis
- 5-year survival rate
- 0.93
- 10-year survival rate
- 0.82
Clinical features by phototype
- Darker phototypes presented more frequently with PAH
- Lighter phototypes had more severe gastro-intestinal manifestations and anti-centromere antibody positivity
- Phototypes determined in 102, ethnicity in 86 patients
Original publication
High prevalence and incidence of systemic sclerosis in Reunion Island, a French multi-ethnical and tropical territory. Semin Arthritis Rheum. Published 19 November 2024. doi:10.
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