Systemic sclerosis & Raynaud's
Association of serum myeloperoxidase with metabolic syndrome and adverse lipid profiles in scleroderma patients
Authors' conclusion
Circulating MPO levels do not correlate with specific SSc disease manifestations. However, higher MPO values are associated with the presence of metabolic syndrome and an unfavorable lipid profile in patients with this condition.
Study context
- Population
- Individuals with confirmed systemic sclerosis (SSc)
- Participants
- 81 individuals
- Outcome
- Association of serum MPO with SSc disease characteristics, lipid profiles, carotid atherosclerosis and metabolic syndrome
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
- No correlation of myeloperoxidase (MPO) with SSc subtype (diffuse or limited), Rodnan skin score, visceral involvement or autoantibody profiles
- Significant positive associations of MPO, after multivariable adjustment, with metabolic syndrome, LDL:HDL cholesterol ratio, non-HDL cholesterol, apolipoprotein B, apolipoprotein B:A1 ratio and atherogenic index
Observational data: associations, not effects.
Original publication
Association of serum myeloperoxidase with metabolic syndrome and adverse lipid profiles in scleroderma patients. Clin Exp Rheumatol. Published 12 November 2024. doi:10.
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