Systemic sclerosis & Raynaud's
Systemic Sclerosis–Associated Myopathy in a Large Single‐Center Cohort: Autoantibody Profiles, Histologic Features, and Independent Risk of Death
Main finding · Risk of death, multivariate Cox regressionResult — go to the resultHazard ratio 1.60 CI 1.32–1.93Authors' conclusion
Skeletal myopathy in SSc is associated with distinct clinical and autoantibody profiles, as well as independently increased risk of death.
Study context
- Population
- Patients in the Johns Hopkins Scleroderma Center Research Registry with Systemic Sclerosis (SSc)
- Participants
- 3,919 patients
- Exposure
- SSc with skeletal myopathy vs without myopathy
- Myopathyn = 672
- Outcome
- Death (survival)
Methodological detailssingle-centre, Cox proportional hazards regression
- Single-centre
- Cox proportional hazards regression
Main finding
Risk of death, multivariate Cox regression
Hazard ratio
1.60
CI 1.32–1.93
P < 0.0001
Myopathyvs No myopathy
HR 1.60 (CI 1.32–1.93); P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Risk of death, univariate Cox regression | 1.59 (1.40–1.81) | P < 0.0001 | |
| 0.512Hazard ratio (log scale) |
Diffuse subtype
P < 0.0001
African American
P < 0.0001
Disease duration at first visit
P < 0.00001
Autoantibodies
- Anti-PM-Scl, U3-RNP and anti-Ku associated with presence of myopathy; anticentromere protective against myopathy
Original publication
Systemic Sclerosis–Associated Myopathy in a Large Single‐Center Cohort: Autoantibody Profiles, Histologic Features, and Independent Risk of Death. Arthritis Care Res (Hoboken). Published 20 January 2026. doi:10.
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