Systemic sclerosis & Raynaud's
The incidence of interstitial lung disease in patients with systemic sclerosis: rate, risk factors and prognostic implications in a EUSTAR cohort analysis (CP 133)
Study context
- Population
- Patients with systemic sclerosis (SSc) without interstitial lung disease (ILD) signs on high-resolution computed tomography (HRCT) at baseline and with at least 1 follow-up visit with available HRCT data, EUSTAR cohortnegative baseline HRCT
- Participants
- 5,331 patients
- Outcome
- Incidence of new-onset SSc-ILD (rate per 100 person-years)
Methodological detailsEUSTAR cohort, generalised logistic estimating equation and Cox regression models
- EUSTAR cohort
- Generalised logistic estimating equation and Cox regression models
Main finding
As reported in the abstract
Incidence of new-onset ILD
Incidence of new-onset ILD, cases per 100 person-years
3.83
Observational data: associations, not effects.
Further findings
Risk factors for new-onset ILD
- Risk factors: New York Heart Association stage ≥2, muscle weakness, high inflammatory markers and SSc-specific autoantibodies, but not disease duration
Prognosis of incident ILD
- Lower risk of ILD progression vs prevalent ILD diagnosed at baseline
- Increased mortality risk, almost double vs ILD-negative cases
Original publication
The incidence of interstitial lung disease in patients with systemic sclerosis: rate, risk factors and prognostic implications in a EUSTAR cohort analysis (CP 133). Ann Rheum Dis. Published 17 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →