Systemic sclerosis & Raynaud's
Clinical predictors of mortality in critically ill systemic sclerosis patients: a 6-year retrospective cohort study
Authors' conclusion
Increased 28-day mortality in critically ill SSc patients is notably linked with higher modified Rodnan skin score and SOFA score at ICU admission, as well as pulmonary hypertension-related right ventricular failure.
Study context
- Population
- Critically ill patients with systemic sclerosis (SSc) admitted to the ICU, 2016–2021
- Participants
- 79 ICU admissions
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Main finding
As reported in the abstract
28-day mortality rate
39.2%
95%CI 28.4–50.9
Higher mRSS (associated with higher mortality), HR
1.11
95%CI 1.06–1.16
Higher SOFA score at ICU admission (associated with higher mortality), HR
1.28
95%CI 1.16–1.41
Pulmonary hypertension-associated right ventricular (RV) failure (associated with higher mortality), HR
10.2
95%CI 2.93–35.2
Observational data: associations, not effects.
Secondary outcomes
Leading causes of ICU admission
- Pneumonia
- 29.1%
- HF
- 26.6%
- Septic shock
- 15.2%
Active SSc-specific organ involvement
- Active carditis
- 25.3%
- Renal crisis
- 13.9%
- Interstitial lung disease (ILD) progression
- 7.6%
- Pulmonary hypertension with RV failure
- 6.3%
Original publication
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